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10
29
th
CONGRESS OF THE ESPU
S1: BASIC RESEARCH 1
Moderators: Yazan Rawashdeh (Denmark), Christian Radmayr (Austria)
ESPU Meeting on Wednesday 11, April 2018, 13:30–15:00
13:30–13:33
S1-1 (PP)
★
HISTOLOGIC FEATURES OF THE EXSTROPHIC BLADDER
BEFORE AND AFTER DELAYED PRIMARY REPAIR:
RESULTS OF AN ONGOING PROSPECTIVE STUDY
Peter RUBENWOLF
1
, Fabian EDER
2
, Stefanie GOETZ
3
, Anne-Karoline EBERT
4
and
Wolfgang H. ROESCH
4
1) University Hospital Frankfurt, Urology, Frankfurt, GERMANY - 2) University Hospital Regensburg, Pathology,
Regensburg, GERMANY - 3) University Hospital Regensburg, Urology, Regensburg, GERMANY - 4) University Hospital
Regensburg, Pediatric Urology, Regensburg, GERMANY
PURPOSE
To investigate the exstrophic bladder at the time of primary bladder closure and subsequently during
secondary procedures in view of histologic alterations and discuss the findings in terms of potential
clinical implications.
MATERIAL AND METHODS
At least 2 bladder biospies from patients with classic BE were obtained a) at the time of delayed
primary repair, b) during secondary reconstructive procedures and c) during subtotal cystectomy for
failed reconstruction. Specimens were examined by a uropathologist for edema, fibrosis, inflamma-
tory, metaplastic and proliferative changes.
RESULTS
As yet bladder specimens from 97 patients (mean age 6,4, range: 0,11–25 years) were analysed.
Edema, fibrosis, inflammatory and proliferative changes were observed in all 3 groups. Dysplastic
or malignant changes were not present. Detailed results are shown in Table 1.
GROUP/Number of pts/ mean age
Histologic feature (%)
A - Primary
delayed closure
n=45; 0,17 yrs.
B - Secondary
procedures
n=37; 7,8 yrs
C - Cystectomy
(failed reconstruction)
n=15; 11,1 yrs
Edema
55
40
20
Fibrosis
48
69
73
Inflammation
95
43
80
Squamous metaplasia
80
43
73
Cystitis cystica/glandularis
83
57
87
Intestinal metaplasia
0
14
53
Dysplasia/malignant neoplasia
0
0
0