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11–14 APRIL, 2018, HELSINKI, FINLAND
S19: LOWER URINARY TRACT 1
Moderators: Luke Harper (France), Seppo Taskinen (Finland)
ESPU Meeting on Friday 13, April 2018, 15:54–16:44
15:54–15:57
S19-1 (PP)
★
IS PEAK CREATININE AFTER BIRTH RELATED
WITH POST RESECTION BLADDER FUNCTION IN INFANTS
WITH POSTERIOR URETHRAL VALVES?
Katerina PRODROMOU
1
, Kalpana PATIL
1
, Arash TAGHIZADEH
1
, Joanna
CLOTHIER
1
, Anne WRIGHT
2
and Massimo GARRIBOLI
3
1) Evelina London Children's Hospital, Paediatric Urology, London, UNITED KINGDOM - 2) Evelina London
Children's Hospital, Paediatric Nephrology and Bladder service, London, UNITED KINGDOM - 3) Evelina London
Children's Hospital, London, UNITED KINGDOM
PURPOSE
In babies born with posterior urethral valves (PUV) bladder and renal function are abnormal. We
aimed to assess whether there is a relation between the two in the first months of life.
MATERIAL AND METHODS
We prospectively collected 4-hour voiding observation data post valve resection of all infants
(0–3 months) with PUV born between July 2015 and July 2017. Data collected were: bladder
capacity (BC), voided volume (VV) and immediate post void residual (PVR) and Peak creatinine
(Pcrea). Estimated bladder capacity (eBC) was determined using Capacity (ml) = 7 × weight (kg)
(Fairhurst et al. J Paediatric Surg 1991:26:55–7). Bladder capacity was considered abnormal if
large or small (>150 % and <65 % eBC respectively). Patients were divided in 2 groups: Pcrea
> 80 umol/L and < 80 uml/L. All results given as median (range). Fisher's exact test was used for
statistical analysis.
RESULTS
Twenty-one male infants, median age 21 days (5–94) were included. All had 4-hour voiding
observation within 7 days (median 1 day) after catheter removal post primary valve resection.
Bladder capacity was abnormal in 12 babies (57 %), being large in 10 (47 %) and small in 2 (9.5 %).
Eleven babies (53 %) had incomplete bladder emptying. In group 1 (12 patients, 57 %), Pcrea was
157.5 umol/L (99–708). In Group 2 (9 patients, 54 %) Pcrea was 77 (48–80). Nor Bladder capacity
(p= 0.39) or incomplete emptying (p= 1) have been found significantly associated with Pcrea.
CONCLUSIONS
Although bladder function immediately post valve resection is found abnormal in the majority of PUV
babies, it does not seems to be associated with the renal function.