Parallel Meeting on Wednesday 3, September 2025, 18:30 - 18:50
18:30 - 18:33
S08-1 (OP)
Kimberley BURROWS 1, Jon HERON 1 and Carol JOINSON 2
1) University of Bristol, Population Health Sciences, Bristol, UNITED KINGDOM - 2) University of Bristol, Centre for Academic Child Health, Population Health Sciences, Bristol, UNITED KINGDOM
PURPOSE
Adverse childhood experiences (ACEs e.g. abuse, neglect, parental psychopathology) have been linked to an increased risk of lower urinary tract symptoms (LUTS). Previous research is, however, limited by reliance on retrospective recall of ACEs, small sample sizes, and is mostly conducted on women. Our study is the first to examine prospective associations between ACEs and LUTS in adolescents.
MATERIAL AND METHODS
We used data from 4745 children from the Avon Longitudinal Study of Parents and Children. Children’s ACE exposure from birth-8-years was reported by mothers, partners and children via 343 questions over 28 timepoints. At age 14, young people completed a self-report questionnaire on LUTS (any urinary incontinence [UI], daytime UI, bedwetting, urgency, nocturia, frequent urination, voiding postponement, low voided volume). We used multivariable logistic regression to examine relationships between the ACE score and LUTS, adjusted for socioeconomic status, maternal antenatal smoking, maternal age at birth of child, parity, ethnicity, birthweight, gestational age, and child developmental delay.
RESULTS
A one unit increase in ACE score was associated with increased odds of UI: Odds ratio (95% confidence interval) 1.16 (1.03-1.30). Odds ratios for the association of ACE score with other LUTS ranged from 1.29 (1.12, 1.48) for urinary frequency to 1.10 (1.02, 1.19) for voiding postponement.
CONCLUSIONS
Children exposed to an increased burden of ACEs are more likely to experience LUTS in adolescence. The findings indicate the importance of assessing ACEs in children presenting with LUTS. ACEs could be targeted in interventions to reduce the risk of LUTS persisting into adolescence.
18:33 - 18:36
S08-2 (OP)
Prince GYAMENAH 1, Kimberley BURROWS 1, Oliver BASTIANI 1, Dheeraj RAI 1 and Carol JOINSON 2
1) University of Bristol, Population Health Sciences, Bristol, UNITED KINGDOM - 2) University of Bristol, Centre for Academic Child Health, Population Health Sciences, Bristol, UNITED KINGDOM
PURPOSE
Children with autism/autistic traits have higher risks of incontinence and constipation. We examine if autistic traits, autism, and genetic liability for autism are associated with incontinence and constipation in children and adolescents in a large birth cohort.
MATERIAL AND METHODS
We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) at ages 9 (n=4233-5539) and 14 (n=3403-4950). We used multivariable logistic regression to examine associations of parent-reported autistic traits (3-9 years) and diagnosed autism with incontinence (enuresis, daytime-wetting, soiling) and constipation (parent-reported at age 9, self-reported at age 14). We used logistic regression analysis to test the association between the autism PRS and incontinence/constipation, adjusted for sex and the first 10 principal components in ALSPAC.
RESULTS
Social-communication and speech coherence difficulties showed the strongest associations with incontinence, e.g. OR and 95% confidence interval for the association between social-communication difficulties and daytime-wetting at age 9 was 2.21 (1.47-3.32) and for coherence was 2.34 (1.60-3.43). Diagnosed autism was only associated with increased odds of daytime-wetting (3.18 [1.44-7.02]). At age 14, there was evidence of associations between autistic traits and constipation: e.g. social-communication (1.68 [1.13-2.49]). The PRS for autism was associated with daytime-wetting at age 14 (1.19 [1.02-1.41]); weakly associated with constipation at age 14 (1.11 [0.99-1.23]), and associated with monosymptomatic, but not non-monosymptomatic, enuresis at age 9 (1.15 [1.03-1.28]).
CONCLUSIONS
We found evidence for phenotypic and genetic associations between autistic traits/autism and incontinence/constipation in a community-based cohort.
18:36 - 18:39
S08-3 (OP)
Terese NILSSON 1, Anna LEIJON 1, Riccardo LOMARTIRE 2, Ulla SILLÉN 3, Anna-Lena HELLSTRÖM 4 and Barbro HEDIN SKOGMAN 1
1) Faculty of Medical Sciences, Örebro University, Örebro, Sweden, Center for Clinical Research Dalarna, Falun, Sweden, Falun, SWEDEN - 2) School of Health and Welfare, Dalarna University, Sweden, Centre for Clinical Research, Falun, Sweden, Falun, SWEDEN - 3) Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden., Department of Pediatric Surgery, Pediatric Uronephrologic Centre, Queen Silvia Children's Hospital, Göteborg, SWEDEN - 4) Institute of Health and Care Sciences, University of Gothenburg, Sweden., Göteborg, SWEDEN
PURPOSE
Late initiation of toilet training is suggested to contribute to functional gastrointestinal disorders in children. This study aims to evaluate if assisted infant toilet training can reduce the prevalence of functional gastrointestinal disorders during the first 9 months of life.
MATERIAL AND METHODS
The Bowel And Bladder function in Infant Toilet Training (BABITT) study is a randomised, controlled trial with healthy infants aged 0-2 months in Sweden. Infants were randomly assigned to either start parent-assisted infant toilet training at the age of 0-2 months (intervention) or after 9 months of age (controls). The intervention group were encouraged to practice at least once a day, 5-7 days per week. All parents answered validated web-questionnaires at ages 2, 3, 6 and 9 months.
The primary outcome was the total period prevalence of parent-reported functional gastrointestinal disorders (infant colic, infant dyschezia and/or functional constipation, defined by Rome IV criteria) up to the age of 9 months.
RESULTS
271 infants (145 males, 54%) were randomly assigned at median age of 34 days (136 intervention; 135 controls). Logistic regression according to intention-to-treat with complete cases (127 intervention; 132 controls) showed no difference in the total period prevalence of functional gastrointestinal disorders between the intervention and the controls (58·3% vs 55·3%, difference 3·0%, [95% CI -9·1 to 15·1]; p=0·6265). Intervention adherence ranged between 53-63%.
CONCLUSIONS
This intervention study does not support that assisted infant toilet training reduces the prevalence of gastrointestinal disorders during infancy. Long-term effects are being evaluated in the ongoing BABITT study up to the age of 4 years.