ESPU Congress 2018 - Abstract Book

41 11–14 APRIL, 2018, HELSINKI, FINLAND 15:53–15:56 S3-7 (PP) EFFICIENCY OF HORMONE STIMULATION TREATMENT BEFORE HYPOSPADIAS SURGERY: EXPERIMENTAL STUDY Ozlem COLOGLU  1 , Murat ALKAN  1 , Emine Bagir KILIC  2 and Seyda ERDOGAN  2 1) Cukurova University, Paediatric Surgery, Adana, TURKEY - 2) Cukurova University, Pathology, Adana, TURKEY PURPOSE In hypospadias surgery, there is no consensus on the choice of hormone preparations, treatment period and surgical timing. The purpose of this study is to observe structural and histopathologi- cal changes of hormone stimulation therapy methods in the healthy (without hypospadias) animal model and evaluate the ideal surgical time period after hormone stimulation. MATERIAL AND METHODS 50 Wistar Albino rats, 4–6 weeks old, were used. Rats were divided into 5 groups as parenteral human chorionic gonadotropin (hCG) group, parenteral testosterone (pT) group, topical dihydrotes- tosterone (tT) group, and control groups of parenteral and topical treatment groups. Penis diameter and length were measured throughout the study and after the application. Biopsies were taken from preputium for histopathological examinations and evaluated for vascularity, epithelial thickness, inflammation and fibrosis. RESULTS Increase of 56 %, 58 %, 84 % in penile length, 62 %, 59.8 %, 109 % in penile diameter, 46 %, 59 %, 100 % in number of vessels, observed in the group of hCG, pT and tT, respectively, of which statistically significant when compared to the control groups. The optimum time for surgical repair starting from the end of hormone administration was found as after the 4 th , 6 th and 1 st week in hCG, pT, and tT groups, respectively. CONCLUSIONS This study has shown that human chorionic gonadotropin, parenteral testosterone and topical dihydrotestosterone treatments are useful in increasing penile size and tissue quality before hy- pospadias surgery. The ideal surgical time period is; 4 th , 6 th and 1 st week after the administration of hCG, pT, and tT, respectively. 15:56–16:17 Discussion